A study that has been followed for 22 years shows that the three methods of Helicobacter pylori radical cure, vitamin supplements, and garlic supplements can effectively reduce the risk of death from gastric cancer by 38%, 52% and 34%, respectively. In terms of preventing death from gastric cancer, the three methods have obvious effects. Eradication of Helicobacter pylori, vitamin supplements and garlic supplements reduced the risk of death from gastric cancer by 38%, 52% and 34%, respectively.

Garlic plays a role of sterilization and cancer prevention is allicin, which is also the source of garlic’s pungent and pungent taste. Allicin can inhibit the activity of enzymes that are conducive to tumorigenesis, and prevent and inhibit Hp infection.

A total of 3365 people participated in the experiment this time. Among them, 2258 Helicobacter pylori-positive participants were divided into 2×2×2 groups and received 2 weeks of Helicobacter pylori eradication, 7.3 years of vitamin supplementation, and/or 7.3 years of garlic supplementation. The remaining 1107 Helicobacter pylori-negative participants received the same vitamin supplements and/or garlic supplements in 2×2 groups.

For the eradication of Helicobacter pylori, 1 g of amoxicillin and 20 mg of omeprazole were used twice a day for two weeks. After that, the breath test was still positive, and the patients who were not cleared of Helicobacter pylori received another course of radical treatment.

People who take vitamin supplements should take a vitamin supplement twice a day, which contains 250mg of vitamin C, 100 IU of vitamin E and 37.5μg of selenium. The tablets for the first 6 months also contain 7.5mg of beta carotene.

Participants who took garlic supplements had to take garlic supplements twice a day. Each medicine contains 200mg of old garlic extract and 1mg of garlic oil obtained by steam distillation.

In the 15-year follow-up results published in 2010, the eradication of Helicobacter pylori showed a significant effect in preventing gastric cancer. Although vitamin and garlic supplementation did not significantly reduce the incidence and mortality of gastric cancer, it also showed some good results. trend. Therefore, the researchers extended the follow-up time to 22 years.

22 years of data show:

  1. In terms of the risk of gastric cancer

Hp treatment for only 2 weeks still has a preventive effect on gastric cancer after 22 years, and the risk of gastric cancer is significantly reduced by 52%;

After 7 years of vitamin intervention, after nearly 15 years, the risk of gastric cancer was significantly reduced by 36%;

Garlic supplements show certain preventive effects, but the overall correlation is not significant

  1. In terms of gastric cancer mortality

All three interventions are related to a significant improvement in gastric cancer mortality.

Hp treatment is associated with a 38% reduction in the risk of death from gastric cancer;

Vitamin supplements are associated with a 52% reduction in the risk of death from gastric cancer;

Garlic supplements are associated with a 34% reduction in the risk of death from gastric cancer.

At each stage, the impact of relevant interventions on the risk of gastric cancer and the mortality of gastric cancer. Combining the previous data of this study, the researchers proposed that Hp treatment is more immediate in preventing the onset of gastric cancer, while the effect of vitamin supplements needs to accumulate over time, but with the passage of time, the preventive effects of both are becoming more and more obvious; In terms of preventing death from gastric cancer, Hp treatment and vitamin supplements are more statistically significant than garlic supplements.

Researchers believe that although Hp treatment has always been regarded as a potential strategy for gastric cancer prevention, since the occurrence and development of gastric cancer involves multiple factors and different stages, the role of Hp treatment and the duration of effective time need to be verified by long-term follow-up. Because the results of this study show that, in the long run, Hp treatment can indeed continue to reduce the risk of gastric cancer, but the impact on gastric cancer mortality 14 years later will be mediocre.

In addition, since Hp infection is mainly related to early precancerous lesions, is there the best time for Hp treatment? As the disease progresses, will Hp treatment still be effective? This point is currently inconclusive.

But in this study, in patients with intestinal metaplasia and abnormal hyperplasia, as well as in the 55-71-year-old elderly population, Hp treatment also reduced the incidence and mortality of gastric cancer. Researchers speculate that, on the one hand, Hp infection may also promote the progression of advanced tumors. On the other hand, Hp treatment may also eliminate other microorganisms related to the occurrence and development of gastric cancer. In other words, regardless of the age of the patient and the progression of the precancerous lesions, Hp treatment may be effective.

It is worth mentioning that there are not many high-quality intervention trials on nutritional support for the prevention of gastric cancer. This research progress also provides the potential value of vitamin and garlic supplements for the prevention of gastric cancer.

  1. Hp is necessary for treatment, please consult your doctor to decide whether to eradicate it.
  2. Supplement vitamins, eat more fresh fruits and vegetables, and eat less pickled and salty foods.
  3. Garlic is a good thing. If you can accept it, you can eat it appropriately (but studies have shown that it is useful to eat more than 5 kg of garlic a year).

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