Magnolia officinalis, the dried bark, root bark and branch bark of the deciduous tree plant Magnolia officinalis Rehd.et Wils. or M.officinalis Rehd.et Wils. var.biloba Rehd.et Wils. The main components of magnolia bark extract are magnolol and honokiol, the main component of magnolia oil volatile oil is eucalyptol, and the alkaloid in magnolia bark extract is magnoline.
At present, the main extracted active ingredients are total magnolol, magnolol and honokiol. Common specifications are 98% magnolol, 98% magnolol and 50%-98% of magnolol. They provide polyphenol antioxidant capacity with good antibacterial and anti-inflammatory effects. Studies have found that Honokiol and Magnolol have stronger antioxidant activity than vitamin E. Honokiol and Magnolo have many special effects, including flushing leucorrhea. In Central America, Honokiol and Magnolol are also used in cataplasm to treat scorpion bites. Magnolia Bark extract is also commonly used in cosmetics as a broad-spectrum antibiotic, antibacterial whitening and natural preservative. Let’s take you to understand the effects of Magnolia officinalis extract!
Study on the Biological Activity and Benefits of Magnolia Bark Extract
1. Antibacterial effect — Magnolia officinalis extract is a natural broad-spectrum antibiotic
Magnolia Bark Extract has an antibacterial effect, and its antibacterial components are stable. In vitro experiments show that Magnolia Bark extract has inhibitory effects on pneumococcus, hemolytic streptococcus, staphylococcus, Escherichia coli, etc.
Magnolol has a strong antibacterial effect, and has obvious effects on dysentery bacillus, typhoid bacillus and carious bacteria, among which the effect on caries bacteria is particularly prominent.
Magnolol and honokiol have the effect of resisting a variety of pathogenic fungi, and can obviously inhibit human diseases such as Candida albicans, Aspergillus niger, epidermal flocculent fungus, Trichophyton flavum, Microsporum gypsum Fungus. Magnolol has higher anti-skin fungal activity than streptomycin sulfate, and has higher anti-stereophyte activity than amphotericin B.
2. Natural preservatives
Magnolia Bark Extract has the characteristics of highly effective inhibition of various bacteria, fungi, and low toxicity. At the same time, magnolol was added to the cream to test its actual antibacterial and antiseptic effect. The results show that the product aroma after adding magnolol is normal, the pH is about 6.2, which is within the normal range, and the cold and heat resistance experiments show that the formula has good stability, which proves that magnolol has a good compatibility when used as a preservative performance.
3. Muscle relaxation
Experiments in mice have shown that Magnolia Bark extract can exert a strong anti-spasm effect. Magnolol has a special and long-lasting muscle relaxation effect in chicken spinal reflex experiments.
4. Effect on the digestive tract
Magnolia officinalis and its volatile oil have a bitter taste and can stimulate the sense of taste, reflexively cause saliva, gastric juice secretion, and gastrointestinal peristalsis to accelerate, and it has the effect of invigorating the stomach and assisting digestion.
5. Anti-ulcer effect
The antiulcer and antisecretory effects of magnolol can be partly attributed to its central inhibitory effect, which is different from the effects of atropine and cimetidine.
6. The effect on the cardiovascular system
Magnolol and honokiol can inhibit the absorption of cholesterol and play a preventive and therapeutic effect on atherosclerosis.
Magnolol has strong antioxidant effect and free radical scavenging activity, suggesting that the cardioprotective ability of magnolol may be related to its antioxidant ability and its ability to inhibit granulocytes.
Magnolol and honokiol have antiarrhythmic effects.
7. Anti-tumor effect
Magnolia officinalis methanol extract and magnolol have a significant inhibitory effect on mouse skin tumors caused by the second phase carcinogenicity test in vivo.
Magnolol can inhibit tumor metastasis in rats.
Magnolol can inhibit the growth of human colon and liver cancer cells.
8. Protective effect on cerebral ischemia
Magnolol can protect brain damage by improving energy metabolism and reducing the generation of oxygen free radicals.
9. Magnolia officinalis extract has a preventive effect on skin aging due to light exposure (anti-inflammatory, anti-allergic, anti-bacterial)
10.The active ingredient of magnolol exerts its antioxidant effect by scavenging oxygen free radicals. According to research on the antioxidant pharmacokinetics of magnolia bark extract, it is proved that magnolia bark extract has a strong antioxidant effect.
11. Magnolol and honokiol have anti-anxiety effects, and honokiol is stronger than magnolol.
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