Project Description
Product Description
Parthenolide is a natural product of sesquiterpene lactones, which is isolated from medicinal plants such as Tansy and Tsoonflower. These plants are widely used for fever, deworming and anti-inflammatory. Parthenolide is a chemical substance with a molecular formula of C15H20O3 and a molecular weight of 248.32. Parthenolide has many important pharmacological activities, such as anti-tumor, anti-viral, anti-inflammatory and anti-atherosclerosis.
Benefits
1. Parthenolide can inhibit the inflammatory protein assembly of a group of oligomer molecules of the innate immune system, and has the effect of inhibiting innate immunity.
2. Parthenolide inhibits IkB protein phosphorylation and NF-KB activation through intracellular mechanisms to play an anti-inflammatory effect.
3. Parthenolide plays a role of chemical anti-cancer and anti-tumor by inhibiting AP-1 and MAP kinase.
4. Parthenolide can induce apoptosis, differentiation and proliferation in some types of cancer cells by inhibiting NF-KB and inducing oxidative stress, and play an anti-platelet effect.
5. Parthenolide has antiviral activity and plays an antiviral effect.
Product Specifications
Purity & Key Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥ 98.0% | HPLC (External Standard) |
| Melting Point | 115 – 118°C | USP <741> |
| Specific Rotation | -70° to -80° (c=0.5, CHCl₃) | USP <781> |
| Loss on Drying | ≤ 0.5% | USP <731> |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Related Substances | Impurity profile verified by HPLC | HPLC (Area Normalization) |
Heavy Metals & Elemental Impurities
| Parameter | Specification | Test Method |
|---|---|---|
| Heavy Metals (as Pb) | ≤ 20 ppm | USP <231> / ICP-MS |
| Arsenic (As) | ≤ 2 ppm | USP <211> / ICP-MS |
| Lead (Pb) | ≤ 10 ppm | USP <251> / ICP-MS |
| Mercury (Hg) | ≤ 1 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS |
Application
Parthenolide is a high-purity research-grade compound valued for its defined chemical structure and consistent quality. Its applications are centered on its use as a reference material and a research tool, primarily within the following domains:
- Pharmaceutical Research & Drug Development
The compound is widely employed in early-stage drug discovery programs, particularly in studies investigating mechanisms of action, cellular signaling pathways, and structure-activity relationships. Its well-characterized profile makes it a suitable lead compound for medicinal chemistry optimization. Researchers utilize it in in vitro and in vivo pharmacological studies to evaluate its potential in various therapeutic areas.
- Cosmetic Ingredient Development
In cosmetic research, parthenolide is investigated for its properties in dermal formulations. It is used in formulation studies to evaluate stability, solubility, and compatibility with other ingredients. Its consistent purity and well-defined characteristics make it a reliable component for research into natural-origin cosmetic actives, without making any specific functional claims.
- Biochemical Research
As a tool compound, parthenolide is utilized in cell-based assays to study its interaction with biological targets, particularly those involved in inflammatory and stress-response pathways. It supports research into cellular mechanisms without implying any therapeutic application.
- Regulatory & Safety Studies
The compound is also used in toxicological and safety evaluations to support regulatory submissions. Its high purity and documented impurity profile contribute to the reliability and reproducibility of these studies, which are critical for the development of new pharmaceutical and cosmetic ingredients.
Packing & Shipping
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