Project Description
Product Description
Levodopais a naturally occurring amino acid and the direct metabolic precursor to dopamine. Our product is derived from the seeds of Mucuna pruriens (velvet bean), a natural botanical source. However, for B2B pharmaceutical and nutraceutical buyers, the critical factors are purity, impurity profile, and batch-to-batch consistency — not the source alone. Our L-DOPA is manufactured under strict quality controls to meet or exceed USP/EP pharmacopoeial standards, ensuring reliable performance in finished formulations.
The product is a white to off-white crystalline powder, used as an active pharmaceutical ingredient (API) in Parkinson‘s disease treatments and as a standardized ingredient in nutraceutical formulations for dopamine support.
Product Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (C₉H₁₁NO₄, on dried basis) | 98.0% – 101.0% | Titration / HPLC |
| Specific Rotation [α]²⁰D | -160° to -175° | Polarimetry |
| Related Substances (Total Impurities) | ≤ 1.0% | HPLC |
| Loss on Drying | ≤ 0.5% | USP <731> |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| Heavy Metals (Total) | ≤ 20 ppm | USP <231> / ICP-MS |
| Lead (Pb) | ≤ 2.0 mg/kg | ICP-MS |
| Arsenic (As) | ≤ 1.0 mg/kg | ICP-MS |
| Mercury (Hg) | ≤ 0.5 mg/kg | ICP-MS |
| Cadmium (Cd) | ≤ 0.5 mg/kg | ICP-MS |
| Residual Solvents | Meets USP <467> | GC |
| Particle Size | As per customer requirement | Sieve Analysis / Laser Diffraction |
| Total Plate Count | ≤ 1,000 CFU/g | USP <61> |
| Salmonella | Negative | USP <62> |
| E. coli | Negative | USP <62> |
Benefits
Applications & Mechanisms
- Primary Therapeutic Applications
Parkinson’s Disease: L-DOPA is the gold-standard treatment for Parkinson’s disease. It alleviates motor symptoms including bradykinesia, rigidity, tremor, and postural instability by replenishing dopamine levels in the striatum. It is most effective in mild-to-moderate cases and can also improve salivation and dysphagia.
Hepatic Encephalopathy: L-DOPA may improve consciousness and neurological symptoms in hepatic encephalopathy by modulating central dopaminergic neurotransmission. It is believed to enhance brain tolerance to ammonia, though it does not directly improve liver function.
Neuropathic Pain: Early administration of L-DOPA has been shown to provide relief in certain neuralgia conditions.
Hyperprolactinemia: By inhibiting thyrotropin-releasing hormone (TRH) and stimulating prolactin-inhibiting factor (PIF), L-DOPA reduces prolactin secretion, making it useful for hyperprolactinemia and associated galactorrhea.
- Mechanism of Action
L-DOPA (levodopa) acts as the direct metabolic precursor to dopamine. Unlike dopamine itself, L-DOPA crosses the blood-brain barrier via the large neutral amino acid transporter (LAT). Once in the brain, it is decarboxylated to dopamine by aromatic L-amino acid decarboxylase (AADC). This increases central dopamine concentrations, compensating for the dopaminergic neuron loss characteristic of Parkinson’s disease and other conditions involving dopamine deficiency. The therapeutic effect is directly correlated with the amount of L-DOPA that reaches the brain and is converted to dopamine.
Other Investigational Uses
- Beyond its primary indications, L-DOPA has been investigated for other applications including:
- Hair growth support: Proposed mechanism involves increasing catecholamine concentrations in tissues, though clinical evidence is limited.
- Growth hormone stimulation: May promote growth hormone secretion and bone development, studied in pediatric growth disorders.
Quality & Compliance
GMP Compliance: Our production facilities follow GMP (Good Manufacturing Practice) guidelines, ensuring consistent quality and purity across all batches. We maintain documented procedures for raw material control, processing, and finished product release.
Available Documentation: Every shipment includes a COA (Certificate of Analysis) and MSDS (Material Safety Data Sheet). We also provide stability data (accelerated and long-term), allergen declarations, non-GMO statements, and residual solvent reports upon request to support your regulatory filings and quality assurance needs.
Quality Standards Followed: Our L-DOPA meets USP (United States Pharmacopeia) and EP (European Pharmacopoeia) standards for identity, purity, and impurities profile, with rigorous testing for related substances, heavy metals, and microbiological contaminants.
Packing & Shipping
Why Choose Us & How to Order?
Located in China, if you purchase from us,we offer many additional convenient services, all of which cannot be easilly provided by other ingeredient products suppliers. Welcome to contact us to get FREE SAMPLE, COA and Nutrition Facts！
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