Berberine Hydrochloride

• Supply Ability : 500-1000 Kilograms Per Month
• Minimum Order Quantity :Only 1 Kilograms
• Packing:Aluminum foil bags,Fiber drums
• Logistics: By Express(5-7 Days), By Air, By Sea
  
• Payment : Western Union , T/T
• Secure transaction

Product Description

Berberine hydrochloride (also known as berberine HCl or natural yellow 18) is a quaternary ammonium salt belonging to the protoberberine group of benzylisoquinoline alkaloids. It is the hydrochloride form of berberine, a bioactive compound extracted from plants such as Coptis chinensis (Chinese goldthread), Phellodendron amurense (Amur cork tree), and Berberis species . The compound has a characteristic yellow color and has been used in traditional Chinese and Ayurvedic medicine for its antimicrobial properties .

Modern pharmacological research has revealed that berberine hydrochloride exhibits polypharmacological activity, modulating multiple biological targets and signaling pathways. Its most well-characterized mechanisms include activation of the AMPK signaling pathway, regulation of gut microbiota and bile acid metabolism, and inhibition of inflammatory signaling cascades . These activities underpin its applications in gastrointestinal health, metabolic support, and immune function. Our Berberine Hydrochloride is available as a high-purity, yellow crystalline powder suitable for dietary supplement, pharmaceutical, and functional food applications.

Benefits & Application

1.Gastrointestinal Health & Antimicrobial Support

Berberine hydrochloride has a long history of use for intestinal infections and gastrointestinal discomfort. It exhibits inhibitory activity against a range of bacteria, with particularly strong effects against Shigella dysenteriae . The compound’s antimicrobial action is primarily localized to the gastrointestinal tract due to its poor systemic absorption when taken orally, making it well-suited for targeting intestinal pathogens . For consumers seeking natural support for digestive wellness and occasional gastrointestinal upset, berberine hydrochloride offers a well-established botanical alternative.

2.Metabolic Regulation & Blood Glucose Support

Berberine hydrochloride has demonstrated significant potential in metabolic health, particularly regarding glucose and lipid metabolism. It activates the AMPK signaling pathway, promoting glucose uptake and utilization while improving insulin sensitivity . Clinical research indicates that berberine may be beneficial in the management of type 2 diabetes, dyslipidemia, and metabolic syndrome . Its hypoglycemic and hypolipidemic effects are achieved partly through remodeling of gut microbiota composition, interference with bile acid reabsorption, and improvement of hepatic glucose metabolism . These mechanisms make berberine hydrochloride a compelling ingredient for metabolic support formulations.

3.Immune Function Enhancement

Recent research has identified a novel role for berberine hydrochloride in innate immunity. A 2025 study demonstrated that berberine hydrochloride enhances resistance against both Gram-negative pathogens (Pseudomonas aeruginosa, Salmonella enterica) and Gram-positive pathogens (Listeria monocytogenes) by activating the p38 MAPK signaling pathway in the intestine . In mouse models, berberine hydrochloride stimulated innate immunity via this pathway and significantly reduced bacterial load in the lungs . This finding suggests therapeutic potential for protecting the host against infectious diseases through immune modulation.

4.Anti-Inflammatory Activity

Berberine hydrochloride exhibits anti-inflammatory effects through multiple molecular mechanisms. Research has shown that it attenuates inflammatory responses by upregulating NAD⁺/NADH-mediated SIRT1 activity, which in turn suppresses NF-κB and MAPK pathway activation . This anti-inflammatory activity contributes to its protective effects in various tissues and supports its traditional use for inflammatory conditions.

5. Cardiovascular & Neuroprotective Potential

Berberine hydrochloride has demonstrated therapeutic potential in cardiovascular diseases, with studies suggesting it may protect against myocardial injury via the HIF-1α/BNIP3 signaling pathway . Additionally, its antioxidant properties and ability to reduce inflammatory biomarkers contribute to vascular protection. Emerging research also points to neuroprotective effects, including modulation of neurotransmitter systems and potential antidepressant-like activity, though clinical evidence in this area remains limited .

Packing & Shipping

Why Choose Us & How to Order?

Located in China, if you purchase from us,we offer many additional convenient services, all of which cannot be easilly provided by other ingeredient products suppliers. Welcome to contact us to get FREE SAMPLE, COA and Nutrition Facts！

Hot Tags: Berberine hydrochloride, berberine HCl, natural yellow 18, Coptis chinensis, Chinese manufacturers, suppliers, factory, wholesale, for sale, bulk