Oxysophocarpine

• Supply Ability : 500-1000 Kilograms Per Month
• Minimum Order Quantity :Only 1 Kilograms
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Product Description

Oxysophocarpine (OSC), also known as sophocarpine N-oxide or sophocarpidine, is a quinolizidine alkaloid derived from plants of the Sophora genus, including Sophora flavescens Ait. and Sophora alopecuroides L. . It is the N-oxide derivative of sophocarpine and presents as a white crystalline powder.

Modern pharmacological research has identified oxysophocarpine as a multi-target compound with documented anti-inflammatory, antioxidant, neuroprotective, and anti-tumor activities . Its mechanisms involve modulation of the NF-κB and MAPK signaling pathways, activation of the Nrf2/HO-1 antioxidant axis, and suppression of pro-inflammatory cytokine production . Emerging studies further suggest potential in inflammatory osteolysis, ulcerative colitis, and hepatocellular carcinoma research .

Benefits & Application

1.Anti-Inflammatory Activity

Oxysophocarpine exhibits potent anti-inflammatory effects through inhibition of the NF-κB and MAPK signaling pathways. Research demonstrates that OSC reduces the production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, while suppressing COX-2 and iNOS expression . In ulcerative colitis models, OSC ameliorated intestinal injury and oxidative stress by repressing the TRAF6/NF-κB axis, reflected in reduced PGE2, MPO, and inflammatory cytokine levels .

2.Antioxidant & Bone-Protective Effects

The compound activates the Nrf2/HO-1 antioxidant signaling pathway, enhancing endogenous defense mechanisms. In osteoclast differentiation models, OSC inhibited intracellular ROS production and suppressed osteoclast-specific gene transcription while increasing Nrf2 and HO-1 protein expression . These findings suggest potential applications in inflammatory osteolytic diseases and bone health research.

3. Neuroprotective Potential

Oxysophocarpine has demonstrated neuroprotective effects in multiple experimental models. Research indicates that OSC protects hippocampal neurons against oxygen-glucose deprivation/reperfusion injury through modulation of the MAPK pathway, and exhibits anticonvulsant effects in pilocarpine-induced seizure models . These properties position OSC as a compound of interest for neuroprotection and seizure-related research.

4.Anti-Tumor Research Interest

Emerging evidence points to anti-tumor potential of oxysophocarpine. Studies have shown that OSC suppresses hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib, partly through FGFR1-related mechanisms . Additionally, OSC has demonstrated inhibitory effects on oral squamous cell carcinoma proliferation, migration, and invasion via the Nrf2/HO-1 axis . These findings support its use as a research tool in oncology investigations.

5.Airway & Respiratory Research

Oxysophocarpine has been shown to protect airway epithelial cells against inflammation and apoptosis by inhibiting miR-155 expression . In vivo and in vitro studies further demonstrate that OSC inhibits airway inflammation and mucus hypersecretion through the JNK/AP-1 pathway, suggesting potential relevance for respiratory inflammation research .

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