Dihydroquercetin

• Supply Ability : 500-1000 Kilograms Per Month
• Minimum Order Quantity :Only 1 Kilograms
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Product Description

Dihydroquercetin (DHQ), also known as Taxifolin, is a natural dihydroflavonol compound belonging to the flavonoid family. It is widely found in plants such as larch (落叶松), Douglas fir, onions, citrus fruits, grapes, and olive oil . Its chemical formula is C₁₅H₁₂O₇, with a molecular weight of 304.25 g/mol and CAS number 480-18-2 .

Dihydroquercetin is characterized by its remarkable antioxidant and anti-inflammatory properties, along with emerging evidence for neuroprotective and metabolic benefits . In 2021, China’s National Health Commission approved DHQ as a new food raw material, permitting its use in specific food categories with defined maximum levels . This regulatory recognition underscores its safety profile and commercial viability for dietary supplement and functional food applications.

Benefits & Application

1.Powerful Antioxidant Activity

Dihydroquercetin is a potent natural antioxidant with a flavonoid structure that enables effective free radical scavenging. It has been shown to enhance endogenous antioxidant defense systems, including upregulation of the KEAP1/NRF2 pathway and increased expression of HO-1 and NQO-1 . These mechanisms protect cells and tissues from oxidative stress, supporting its application in anti-aging and cellular protection formulations.

2. Neuroprotective & Cognitive Support Potential

Emerging research highlights DHQ’s potential in brain health. A 2026 study demonstrated that dietary DHQ significantly alleviated age-related cognitive impairment in animal models by reducing neuroinflammation (decreased TNF-α, IL-1β, IL-6) and modulating neuronal apoptosis and pyroptosis pathways . Additional research indicates DHQ may improve impaired brain function associated with metabolic syndrome through regulation of the HIF-1α/AKT/NR2B signaling pathway . These findings position DHQ as a promising ingredient for cognitive support and healthy aging formulations.

3. Metabolic & Liver Health Support

Preclinical studies suggest DHQ exerts hepatoprotective effects relevant to metabolic dysfunction-associated steatotic liver disease (MASLD). Research indicates DHQ modulates the HIF-1α/VEGF pathway and may inhibit lipogenesis and regulate lipid metabolism . Its antioxidant and anti-inflammatory properties contribute to these metabolic benefits, making it a candidate for liver-health and metabolic-support products.

4.Anti-Inflammatory Activity

DHQ exhibits anti-inflammatory effects through suppression of pro-inflammatory cytokine production and modulation of key signaling pathways. In neuroinflammation models, DHQ treatment reduced levels of TNF-α, IL-1β, and IL-6 . Research also indicates DHQ protects dopamine neurons by regulating microglial TREM2 activation and inhibiting microglia-elicited neuroinflammation .

5.Food & Beverage Antioxidant Application

As an approved new food raw material in China, DHQ is permitted for use as an antioxidant in various food categories. Regulatory maximum usage levels include: 20 mg/L for beverages, 20 mg/kg for fermented milk, and 70 mg/kg for cocoa products and chocolate . The recommended daily intake is ≤100 mg, with labeling requirements noting that infants, children under 14, pregnant and nursing women should not consume it . This regulatory framework supports DHQ’s use as a natural antioxidant in functional food and beverage development.

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