Project Description
Welcome to XianHerb.com, your trusted source for premium herbal extracts and natural ingredients. Today, we are excited to introduce our exceptional product – Concanavalin, a versatile solution that resonates with our esteemed end customers, traders, and sellers in the food and beverages industry.
At XianHerb.com, we are committed to nurturing health, innovation, and happiness through nature’s brilliance. Embrace the essence of Concanavalin and embark on a journey to culinary delight and enhanced well-being.
Product Description
Concanavalin A (Con A) is a legume lectin purified from the seeds of the Jack bean (Canavalia ensiformis). It is a tetrameric metalloprotein, with a molecular weight of approximately 104 kDa (tetramer), composed of four identical subunits of about 26 kDa each. Con A is a well-characterized carbohydrate-binding protein that specifically recognizes and binds to α-D-mannosyl and α-D-glucosyl residues in a metal-ion-dependent manner, requiring calcium and manganese ions for its activity . As a mitogenic lectin, it is widely used as a research tool in immunology, cell biology, and glycobiology.
Product Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Purity | ≥ 95% (SDS-PAGE); ≥ 99% (HPLC, as per customer requirements) | SDS-PAGE / HPLC |
| Hemagglutination Activity | ≥ 10,000 U/mg | Hemagglutination Assay |
| Subunit Molecular Weight | ~ 26 kDa (monomer) | SDS-PAGE |
| Appearance | White to off-white lyophilized powder | Visual Inspection |
| Solubility | Soluble in water and PBS (phosphate-buffered saline) at 1-10 mg/mL | Visual |
| pH Range (for activity) | Optimal pH 7.0 – 8.5 | Activity Assay |
| Metal Ion Requirement | Calcium (Ca²⁺) and Manganese (Mn²⁺) required for activity | Activity Assay |
| Storage Condition | 2 – 8°C (short-term); -20°C (long-term). Protect from light. | / |
| Heavy Metals (Total) | ≤ 10 ppm | ICP-MS / AAS |
| Endotoxin Level | ≤ 1.0 EU/µg (for cell culture grade; as per customer requirement) | LAL Test |
| Total Plate Count | ≤ 1,000 CFU/g | USP <61> |
| E. coli | Negative | USP <62> |
| Salmonella | Negative | USP <62> |
Benefits
- Concanavalin has anti-tumor effect. It can also restore some tumor cells to the growth state of normal cells.
- Concanavalin can enhance disease resistance. It can maintain the normal metabolic function of the human body and promote the activity of various enzymes in the human body, thereby enhancing the antibody immunity and improving the human disease resistance.
- Concanavalin can effectively prevent cancer and fight cancer. It has the effect of treating hepatic coma and anti-cancer.
Concanavalin offers a diverse range of functions that elevate culinary creations and promote health. Its unique binding properties can be harnessed to improve the texture and stability of food and beverages. Additionally, Concanavalin may have potential applications in controlling blood sugar levels, making it of interest to those seeking to manage their glycemic response.
Key Properties & Research Applications
Concanavalin A is a valuable tool in life science research, with its value derived from its specific biochemical properties rather than direct therapeutic use. Its key applications include:
Specific Carbohydrate Binding: Con A is a lectin with high specificity for terminal α-D-mannosyl and α-D-glucosyl residues. This property makes it an excellent probe for detecting and characterizing glycoproteins on cell surfaces and in solution . It is also used for the isolation and purification of glycoproteins and polysaccharides.
Lymphocyte Activation & Proliferation: Con A is a potent T-cell mitogen, meaning it can stimulate T-lymphocytes to undergo blast transformation and proliferation. This property is fundamental to immunological research, allowing scientists to study T-cell signaling, cytokine production, and immune responses in vitro.
Cell Agglutination: Due to its tetravalent structure, Con A can cross-link cells by binding to carbohydrate moieties on their surface, leading to cell agglutination. This is utilized in applications such as blood typing, cell membrane studies, and the characterization of cell-surface carbohydrates in various cell types.
Molecular Biology: Con A is also used in affinity chromatography for the purification of glycoproteins and for the histochemical staining of tissue sections to reveal specific carbohydrate patterns.
Packing & Shipping
Why Choose Us & How to Order?
Located in China, if you purchase from us,we offer many additional convenient services, all of which cannot be easilly provided by other ingeredient products suppliers. Welcome to contact us to get FREE SAMPLE, COA and Nutrition Facts！
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